Two meters of DNA in micron size cell nucleus: the role of topological constraints in genome folding

Alexander Grosberg
New York University
Thursday, March 15, 2012
UNC, Chapman 125 | 4:00pm

Each cell of our body contains about two meters worth of DNA packed in a cell nucleus with diameter about 5 micrometers. Moreover, each piece of DNA remains accessible for manipulations by the cell machinery. Recent experiments confirmed the 20 years old theoretical idea as to how DNA can be both densely packed and manageable. In this lecture, these experiments will be reviewed along with the renewed theoretical efforts to understand the genome folding quantitatively.

Please note this seminar is at UNC