IRG2 Technology

Programmable Liquid, Gel, and Biohybrid Compartments

Lopez, G.; Chilkoti, A.; Carroll, N.; Simon, J.

Researchers at Duke University have developed a platform to program the assembly of proteins and polymers into complex particle architectures. The Duke approach enables programming of materials at the building block level, which is implementable over a large range of size, production scales and applications. For more info, click here .

Contact: Gabriel Lopez (gl52@duke.edu)

Systems and Devices for Protease Detection Based on Engineered Polymers and Biopolymers and Methods of Use

Lopez, G.; Chilkoti, A.; Ghoorchian, A.; Quiroz, F.

Unregulated changes in protease activity are linked to many diseases including cancer, infectious, inflammatory and even cardiovascular diseases. The concentration and activity of proteases are precisely regulated in vivo and disruption of this homeostasis is linked to a number of pathological disorders, from inflammatory and cardiovascular disease to cancer and neurological abnormalities. The ability to detect changes in protease activity is thus a powerful potential means for diagnosing protease-related diseases, as well as for discovering new drugs against these maladies. We developed accurate and low cost assays for detection of these changes. For more info, click here .

Contact: Gabriel Lopez (gl52@duke.edu)

Micro- and Macro-hydrogels formed from polypeptide micelles and their applications

Lopez, G.; Chilkoti, A.; Ghoorchian, A.; Simon, J.

Researchers at Duke University have developed biocompatible, mechanically robust and tunable, peptide-based, self-healing hydrogel platform technology that can be used in a variety of biomedical applications. For more info, click here .

Contact: Gabriel Lopez (gl52@duke.edu)

Phase Transition Biopolymers and Methods of Use

Chilkoti, A.; Garcia-Quiroz, F.; Amiram, M.

Researchers at Duke University have discovered a family of new amino acid motifs, that when polymerized display lower critical solution temperature (LCST) phase behavior. These sequences display a range of cloud points and different degrees of thermal hysteresis. This amily of new LCST peptide polymers provide a diverse set of polymers for a range of applications. For more info, click here .

Contact: Ashutosh Chilkoti (chilkoti@duke.edu)